Stellarex EnduraCoat technology

Stellarex, with EnduraCoat technology combines amorphous and small-to-large crystalline paclitaxel with polyethylene glycol excipient. The result is efficient drug transfer, effective tissue residency, high coating durability and minimal particulate loss.

0.014" DCB is not approved for distribution, sale or use in the USA.
Availability of this product may vary by country.

Hybrid paclitaxel (PTX) formulation

Amorphous PTX

enhances coating durability and prompt drug availability for immediate action and short-term residency7

Crystalline PTX

forms drug depots that dissolve into tissue slowly for sustained residency7

PEG HAp

Polyethylene glycol (PEG) excipient

  • PEG’s durability, adhesion, flexibility, elongation and elasticity may help prevent premature drug loss during handling, tracking and inflation
  • Due to its high molecular weight, PEG dissolves slowly to help protect low dose of PTX
  • PEG forms strong ionic bonds with hydroxyl apatite (HAp),12 the primary component of calcified atherosclerotic lesions, which may limit PTX washout in the presence of calcium

High transfer efficiency and effective residency9,11

Stellarex EnduraCoat technology achieves uniform and acute drug transfer and sustained tissue residency at therapeutic levels through 28 days, minimizing restenosis.

ng PTX/mg of tissue
0.1
1
10
100
Days after treatment
0
5
10
15
20
25
30
35
Stellarex
In.Pact
Lutonix

Low particulate loss

Stellarex demonstrates low particulate loss,9 which may reduce the risk of downstream embolization and, at the same time, enable a low therapeutic drug dose.

Number of particulate ≥10µm/mL (x100)
0
1
2
3
4
5
Stellarex

In.Pact

Lutonix

Anti-restenotic effect

A comparative study of Stellarex versus PTA in a swine model of in-stent restenosis demonstrates Stellarex DCB’s efficacy at 28 days, indicated by minimal luminal loss and consistent treatment effect.9

Treatment (Day 1)
Day 28
Stellarex
PTA
Day 1
Day 28

See more about the Stellarex difference

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